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			Epidemiologic research on lung damage caused by humidifier disinfectants							
		
		Moo-Song Lee, Hwa Jung Kim		
			Epidemiol Health. 2016;38:e2016031.   Published online July 20, 2016		
							DOI: https://doi.org/10.4178/epih.e2016031
					
					 
		
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						 Abstract  Summary  PDF  Supplementary Material
		AbstractIn April 2011 a tertiary hospital located in Seoul, Korea reported several cases of severe respiratory distress of unknown origin in young adults. To find the route of transmission, causative agent and patient risk factors of the outbreak, an investigation of the epidemic was initiated. A hospital based case-control study was conducted to indicate that humidifier detergent use was the cause of the outbreak. This information led the Ministry of Health and Welfare of Korea issued an order that humidifier detergents should be withdrawn from the market. Here, we describe the major events of planning, execution, and interpretation of the study, and discussions between researchers and public authorities following the decision to perform an epidemiologic study, chronologically.
			Summary 
						Korean summary본 역학조사는 일개 병원에서 신고한 질병 유행에 대해 다학제적 연구 결과로써, 질병의 임상적 특성과 역학적 원인 파악 후 정책적 대책으로 이어진 사례이다. 향후 가습기 살균제 이외에도 일반국민의 건강에 영향을 미칠 수 있는 다양한 생활환경요인에 관심을 가지고, 필요 시 적극적인 조사와 대응이 필요할 것이다.
			Citations Citations to this article as recorded by   Prenatal and Childhood Exposure to Humidifier Disinfectants and Attention-Deficit/Hyperactivity Disorder (ADHD): Insights from a Retrospective Cohort DesignHyowon Choi, Hunju Lee, Yeon-Soon Ahn
 Toxics.2025; 13(2): 78.     CrossRef
Evaluating Metabolic Signatures in the Serum of South Korean Patients with Humidifier Disinfectant–Associated Lung Injury Identified through Untargeted MetabolomicsJinwoo Kim, Mi-Jin Kang, So-Yeon Lee, Sang-Bum Hong, Ho Cheol Kim, Myung Hee Nam, Soo-Jong Hong
 Environmental Health Perspectives.2025;[Epub]     CrossRef
Is Polyhexamethylene Guanidine and Oligo(2-(2-Ethoxy) Ethoxyethyl Guanidium Chloride Exposure Related to Gestational Diabetes?Hyowon Choi, Nam-Yun Kim, Nalai Kim, Yeon-Soon Ahn
 Toxics.2024; 12(12): 841.     CrossRef
Evaluation of polyhexamethylene guanidine-induced lung injuries by chest CT, pathologic examination, and RNA sequencing in a rat modelCherry Kim, Sang Hoon Jeong, Jaeyoung Kim, Ki Yeol Lee, Jaehyung Cha, Chang Hyun Lee, Eun-Kee Park, Ju-Han Lee
 Scientific Reports.2021;[Epub]     CrossRef
Comparison of Long Term Follow-up Chest CT Imaging in Adult and Pediatric Patients with Humidifier Disinfectant-related Lung InjurySoyeoun Lim, Jong Han Leem, Young-Seoub Hong, Jungwon Kim, Soyoung Park, Joon-Sung Joh, Woon-Jung Kwon, Yangho Kim
 Journal of Korean Medical Science.2020;[Epub]     CrossRef
Guanidine-based disinfectants, polyhexamethylene guanidine-phosphate (PHMG-P), polyhexamethylene biguanide (PHMB), and oligo(2-(2-ethoxy)ethoxyethyl guanidinium chloride (PGH) induced epithelial-mesenchymal transition in A549 alveolar epithelial cellsYong Joo Park, Mi Ho Jeong, In Jae Bang, Ha Ryong Kim, Kyu Hyuck Chung
 Inhalation Toxicology.2019; 31(4): 161.     CrossRef
Development of QSAR Model for Subchronic Inhalation Toxicity Using Random Forest Regression MethodJae Hong Shin, Byeong Hun Lee, Sung Kwang Lee
 Bulletin of the Korean Chemical Society.2019; 40(8): 819.     CrossRef
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