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Estimated incidence of juvenile-onset recurrent respiratory papillomatosis in Korea
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Jin-Kyoung Oh, Hwa Young Choi, Minji Han, Yuh-Seog Jung, Sang Joon Lee, Moran Ki
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Epidemiol Health. 2021;43:e2021019. Published online March 10, 2021
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DOI: https://doi.org/10.4178/epih.e2021019
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Abstract
OBJECTIVES
Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 and 11 and is potentially preventable through vaccination. This study estimated the incidence of juvenile-onset RRP before the implementation of the national HPV vaccination program in Korea.
METHODS We conducted a cohort study using claims data provided by a mandatory insurance program to estimate the incidence of RRP and associated healthcare use. Patients with juvenile RRP were defined as those aged ≤12 years with ≥2 admissions or ≥2 outpatient visits during which they received the International Classification of Diseases, 10th revision code for benign neoplasms of the larynx (D14.1).
RESULTS During 2002-2014, 123 children (74 boys and 49 girls) were diagnosed with RRP. The patients had a mean of 6.5 person-years of follow-up. The incidence was estimated at 0.30/100,000 person-years. The median age at diagnosis was 4.0 years (mean, 4.3). Thirty-six (29.3%) patients underwent surgery, including 23 patients (18.7%) who underwent 2 or more surgical procedures. Severe disease, measured by more frequent surgical procedures and shorter time intervals between consecutive operations, was associated with a younger age at diagnosis.
CONCLUSIONS The estimated incidence of juvenile-onset RRP in Korea was similar to that reported in other countries. The RRP burden should continue to be monitored using National Health Insurance Service claims data.
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Summary
Korean summary
재발성호흡기유두종증은 사람유두종바이러스에 의해 발현되는 희귀 질환이다. 건강보험 청구자료를 활용하여 2002년 이후 출생아 전수 중 2014년까지 후두양성종양으로 2회이상 입원 또는 2회이상 외래진료를 받은 어린이 코호트를 관찰하여 재발성호흡기유두종증 발생률을 추정하였다. 총 123명의 재발성호흡기유두종증 환자가 발생하였으며 (발생률 10만인년당 0.30명), 평균 첫 진단시기는 4세인 것으로 나타났다. 2회 이상 수술적 치료를 받은 경우는 18.7%였다.
Key Message
Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV). We conducted a cohort study using claims data to estimate the incidence of RRP. Patients with juvenile RRP were defined as those aged ≤12 years with ≥2 admissions or ≥2 outpatient visits with diagnosis for benign neoplasms of the larynx. During 2002-2014, 123 children were diagnosed with RRP. The incidence was estimated at 0.30/100,000 person-years. The median age at diagnosis was 4.0 years. Twenty three patients (18.7%) underwent 2 or more surgical procedures.
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Citations
Citations to this article as recorded by  - Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: A hospital-based nationwide study
Changchang Dun, Yutong Li, Wenbin Lei, Yun Li, Hui Yang, Yalikun Yasen, Nilipaer Alimu, Dapeng Lei, Dongyan Chen, Qingquan Hua, Zhen Xu, Zhe Zhang, Guangke Wang, Weiwei Wang, Li Shi, Xin Wang, Xuelian Zhao, Shangying Hu, Xiaoguang Ni, Jie Zhang, Jun Wang,
International Journal of Infectious Diseases.2025; 158: 107972. CrossRef - "A systematic literature review of the epidemiology, clinical, economic and humanistic burden in recurrent respiratory papillomatosis”
Olga Ovcinnikova, Kayla Engelbrecht, Meenu Verma, Rishabh Pandey, Edith Morais
Respiratory Research.2024;[Epub] CrossRef - Global Epidemiology of HPV-Associated Recurrent Respiratory Papillomatosis and Effect of Vaccination
RY Seedat, FG Dikkers
Future Virology.2022; 17(5): 265. CrossRef
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